An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange
نویسندگان
چکیده
منابع مشابه
Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.
A mild and general method for the conversion of aryl, heteroaryl, and vinyl bromides into the corresponding iodides was developed utilizing a catalyst system comprising 5 mol % of CuI and 10 mol % of a 1,2- or 1,3-diamine ligand. A variety of polar functional groups are tolerated, and even N-H containing substrates such as sulfonamides, amides, and indoles are compatible with the reaction condi...
متن کاملThe mystery of the Finkelstein reaction
© Rzepa This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. This story starts with an organic chemistry tutorial, when a student asked for clarification of the Finkelstein reaction. This is a simple SN2 ...
متن کاملNickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides.
A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer's disease and iniparib, a compound used in the treatment of breast cancer.
متن کاملPhosphazene base-promoted halogen-zinc exchange reaction of aryl iodides using diethylzinc.
The use of catalytic t-Bu-P4 base dramatically improved the performance of halogen-zinc exchange of aryl iodides, and the arylzinc derivatives were functionalized under copper-free reaction conditions.
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The scientific literature contains a tremendous amount of kinetic data describing the dynamic behaviour of biochemical reactions over time. These data are needed for computational modelling to create models of biochemical reaction networks and to obtain a better understanding of the processes in living cells. To extract the knowledge from the literature, biocurators are required to understand a...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2019
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c9ob01625b